Docteur André GIBERT - Hépato- Gastro- Entérologie
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cancer oesophagien et alcool

(Freedman ND et al. Gut. 2011 Aug; 60(8): 1029-37) 
L'effet néfaste de l'alcool et de l'association alcool et tabac sur le cancer épithélial de l'oesophage est reconnu. Le rôle pathogénique de l'alcool sur l'adénocarcinome oesophagien reste mal connu. L'analyse de plusieurs études de malades atteints de cancer de l'oesophage et d'endobrachyoesophage ont permis d'analyser 1821 adénocarcinomes de l'oesophage, 1837 cancers de la jonction oesogastrique, 1016 cancers épithéliaux et 10854 témoins. Il en ressort que l'alcool n'augmentait pas la survenue des adénocarcinomes ou des cancers du cardia quelle que soit la quantité d'alcool consommée. Par contre, l'association est confirmée pour le carcinome épidermoïde avec un risque proche de 10 pour une consommation de plus de 7 verres par jour.

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