Docteur André GIBERT - Hépato- Gastro- Entérologie
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effets des IPP et régurgitations

 (Kahrilas PJ et al. Am J Gastroenterol. 2011 Aug; 106(8): 1419-25)
 Les inhibiteurs de la pompe à proton (IPP) ont révolutionné le traitement du reflux gastro-oesophagien (RGO). De nombreuses études ont montré que les régurgitations étaient résistantes à ces traitements. Une revue de la littérature portant sur sept essais thérapeutiques indiquent un gain thérapeutique des IPP sur les régurgitations de seulement 17% comparé au placebo, et une infériorité de plus de 20% comparé à l'effet des ces médicaments sur le pyrosis. Ces données montrent que le bénéfice des IPP sur les régurgitations est modeste, ces dernières devant être considérées comme un facteur de résistance aux IPP.

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