Docteur André GIBERT - Hépato- Gastro- Entérologie
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Dépistage du cancer colorectal
Hypersensibilité au gluten et intestin irritable
Performance de la vidéocapsule colique
Résistance d'Helicobacter pylori aux antibiotiques
nouveau traitement pour l'éradication d'Helicobacter pylori (Megraud F. Therap Adv Gastroenterol. 2012

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IPP et infections

Les inhibiteurs de la pompe (IPP) à protons sont parmi les médicaments les plus vendus dans le monde. Leurs effets secondaires sont peu nombreux. La prise prolongée, n'est pas sans conséquence, l'inhibition de la sécrétion gastrique acide favorise la prolifération microbiennes dans l'intestin grêle. Une trentaine d'études pour lesquelles ce risque a été évalué montre que les IPP augmentent les infections par les salmonelles, Campylobacter, Clostridium difficile, Vibrio cholera et Listeria avec des risques évoluant de 4 à 10 en fonction des micro-organismes. Les conséquences cliniques sont importantes pour les malades hospitalisés, en particulier les immunodéprimés, et aussi pour les voyageurs en pays tropicaux. Ainsi, il pourrait être pertinent de suspendre la prise d'IPP pendant un voyage en pays tropical dans le but de limiter la survenue des gastroentérites, qui sont maintenant reconnues comme un véritable problème de santé publique pour les voyageurs.
 Bavishi C et al. Aliment Pharmacol Ther. 2011 Oct 17 [Epub ahead of print])
 

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