Docteur André GIBERT - Hépato- Gastro- Entérologie
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constipation et acides biliaires

(Chey WD et al. Am J Gastroenterol. 2011 Oct; 106(10): 1803-12) 
Le traitement de la constipation chronique de l'adulte repose sur l'utilisation de laxatifs avec des effets souvent aléatoires. Il est possible d'agir sur le métabolisme des acides biliaires dont l'effet laxatif est reconnu. Dans cette étude, les auteurs ont envisagé l'effet bénéfique d'un inhibiteur du transport iléal des acides biliaires au cours d'un essai thérapeutique. Les résultats montrent une augmentation significative et dose dépendante du nombre de selles par semaine après sept jours de traitement. Le bénéfice thérapeutique était maintenu pendant les deux mois.  La diarrhée et des douleurs abdominales étaient les effets secondaires les plus courants. Cette étude confirme le bénéfice thérapeutique des acides biliaires dans l'arsenal thérapeutique de la constipation.
 

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