Docteur André GIBERT - Hépato- Gastro- Entérologie
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tabac et endobrachyoesophage

Barrett(Coleman HG et al. Gastroenterology. 2011 Nov 3 
 Le cancer de l'oesophage développé sur endobrachyoesophage a un pronostic très sombre.
Les facteurs influençant le risque de progression de l'endobrachyoesophage (EBO) permettront peut-être d'envisager des moyens de prévention. Dans cette étude ont été analysé la hauteur de l'EBO,la consommation d'alcool et de tabac sur la transformation de l'EBO en cancer.
Parmi ces malades, seulement 117 ont développé un cancer ou une dysplasie de haut grade. Le tabagisme actif était significativement associé au passage de la dysplasie vers le cancer avec un effet dose-dépendant. En revanche, l'alcool n'augmentait pas le risque de transformation, de même que la taille de l'EBO. en conclusion, le risque de dégénérescence de l'EBO est deux fois plus élevé chez les fumeurs, d'où l'importance du sevrage pour prévenir l'adénocarcinome

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